منابع مشابه
Population Responses of Microtus pennsylvanicus across a Chronological Sequence of Habitat Alteration
Understanding the effects of habitat alteration on population demography and persistence is emerging as one of the most important and challenging areas facing ecologists and conservation biologists today. Here we compare the population demography of a common but important consumer species in eastern and mid-western grassland communities (Microtus pennsylvanicus) across three habitats that diffe...
متن کاملNew phenotypes associated with mucAB: alteration of a MucA sequence homologous to the LexA cleavage site.
Most mutagenesis by UV and many chemicals in Escherichia coli requires the products of the umuDC operon or an analogous plasmid-derived operon mucAB. Activated RecA protein is also required for, or enhances, this process. MucA and UmuD proteins share homology with the LexA protein, suggesting that they might interact with the RecA protein as LexA does. We used oligonucleotide-directed mutagenes...
متن کاملAlteration of Sequence Specificity of the Type IIS Restriction Endonuclease BtsI
The Type IIS restriction endonuclease BtsI recognizes and digests at GCAGTG(2/0). It comprises two subunits: BtsIA and BtsIB. The BtsIB subunit contains the recognition domain, one catalytic domain for bottom strand nicking and part of the catalytic domain for the top strand nicking. BtsIA has the rest of the catalytic domain that is responsible for the DNA top strand nicking. BtsIA alone has n...
متن کاملStratifying tumour subtypes based on copy number alteration profiles using next-generation sequence data
MOTIVATION The role of personalized medicine and target treatment in the clinical management of cancer patients has become increasingly important in recent years. This has made the task of precise histological substratification of cancers crucial. Increasingly, genomic data are being seen as a valuable classifier. Specifically, copy number alteration (CNA) profiles generated by next-generation ...
متن کاملSequence-Specific Alteration of the Ribosome–Membrane Junction Exposes Nascent Secretory Proteins to the Cytosol
Tight docking of the ribosome at the translocation channel ensures that nascent secretory proteins are shielded from the cytoplasm during transfer into the endoplasmic reticulum. Discrete pause transfer sequences mediate the transient stopping of translocation in certain proteins. Here we show that during a translocational pause, the junction between the ribosome and translocation channel is op...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2000
ISSN: 1059-7794,1098-1004
DOI: 10.1002/(sici)1098-1004(200001)15:1<122::aid-humu38>3.0.co;2-o